Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Plaquenil urticaria treatment Hydroxychloroquine fibromyalgia Toxicity of hydroxychloroquine Previous 30 recommendations by the AAO to limit HCQ dosing to 6.5 mg/kg of ideal body weight have been 31 revised to 5 mg/kg of actual body weight 5. Some authors recommend 6.5 mg/kg of actual 32 body weight with a cap at 400 mg per day and further adjustments for renal insufficiency 10. Aug 30, 2011 A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. However, there have been case reports of patients with hydroxychloroquine toxicity as early as 1.9 months after starting treatment 11. Depending on the patient's condition, the dosage can be tapered at those visits. After 3-6 months, the dose should be tapered to physiolog- ic levels – for example, 10 mg of prednisone per day or less. corticosteroids, one should consider the addition of a steroid-sparing agent, such as methotrexate or azathioprine. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Chloroquine dosage ophthalmology guidelines My Take on New Ocular Screening Guidelines for Plaquenil., Hydroxychloroquine Plaquenil Toxicity and Recommendations. What are some of the side effects of plaquenilHydroxychloroquine lung diseasePlasmodium resistance to chloroquineCan plaquenil treat acid refluc The American Academy of Ophthalmology’s recommendations for screening of chloroquine CQ and hydroxychloroquine HCQ retinopathy were published in 2002. The new guidelines also recommend that in addition to 10-2 automated fields, at least one of the newer objective tests be used, such as multifocal electroretinogram, spectral domain. New guidelines to minimize toxic damage from chloroquine.. SARCOIDOSIS TREATMENT GUIDELINES. Hydroxychloroquine Plaquenil. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Mar 15, 2019 Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Occurs. They should take one dose per week while there, and for 4 consecutive weeks after leaving. The weekly dosage for adults is 300mg base 500mg salt. Your doctor will have calculated the correct weekly. dose for your child based on the child’s weight. The child’s dose should not exceed the adult dose of 300mg base 500mg salt per week.