Despite drastic containment measures, the spread of this virus is ongoing. SARS-Co V-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans. Can plaquenil cause breast cancer Naltrexone and plaquenil Chloroquin doses It is found to induce rapid clumping of the pigment. Chloroquine inhibits the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. It may also interfere with the biosynthesis of nucleic acids. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species ROS related to tumor reoxygenation. Addition of chloroquine to the incubation mixture, at a concentration of 1 or 10 mM, resulted in a significant inhibition of the nucleic acids and protein synthesis. Therefore, this effect on retinal nucleic acid and protein synthesis may be important in the pathogenesis of retinal disease observed during chloroquine therapy. In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-Co V-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-Co V-1. The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. Chloroquine interfere nucleic acid biosynthesis Antimalarial drug proves effective on COVID-19 patients - CGTN, Chloroquine - My Cancer Genome Can chloroquine injection terminate pregnancyChloroquine mechanism of action iodine The nucleotide metabolism page discusses the biosynthesis and degradation of the nucleic acids as well as descriptions of diseases caused by defects in their metabolism. Nucleotide Metabolism Nucleic Acid Synthesis and Catabolism. In vitro action of chloroquine on nucleic acid and protein.. THE BIOSYNTHESIS OF NUCLEIC ACID COMPONENTS STUDIED WITH Cl4. Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria except for disease caused by chloroquine resistant Plasmodium falciparum. It may also interfere with the biosynthesis of nucleic acids. The mechanism is that the chloroquine can interfere with the biosynthesis of nucleic acids, thus preventing DNA replication and RNA transcription. The use of Chloroquine phosphate was banned in. Availability. Hydrochloride 250 mg, 500 mg tablets; 5 mg, 50 mg/mL ampule Phosphate 250 mg, 500 mg tablets Actions. Antimalarial activity is believed to be based on its ability to form complexes with DNA of parasite, thereby inhibiting replication and transcription to RNA and nucleic acid synthesis.