I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Hydroxychloroquine cyp Plaquenil tablets 200mg I was reading the other post on plaquenil and it really can make a difference and you don't realize it until you just stop taking it! Needless to say, I regret my choice, but I don't know what to do about my skin issue either Some people need long-term treatment with low-dose steroids; others can stop taking them altogether. Steroids also come as a topical treatment, which can help treat skin rashes caused by lupus. Hi honey, YES.stopping plaquenil for a couple of days can cause symptoms to arise or get worse.needs to be taken exactly as prescribed. Twice a day, every day. Missing one dose wont make a major difference but skipping more then one, or days absolutely can. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. What will happen if you stop taking plaquenil Statins What happens to patients who stop taking them after., Lupus Medications and Treatments Plaquenil forum I can't believe you were told to stop taking plaquenil after only 6 months since it can take up to one YEAR to achieve full benefits! I don't know much about any sort of withdrawal but if I were you I'd start taking it again. I'd also have your thyroid checked. I'm hypothyroid and take levo along with he plaquenil. Hydroxychloroquine plaquenil withdrawl? - LUPUS UK. Stopping plaquenil. DailyStrength. Can you just stop taking plaquenil or do you have to wean off.. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs. Aug 26, 2016 Plaquenil is supposed to stay in your system for 1-2 months after you stop taking it. Try to rest, stay hydrated and away from sick ppl for now and hopefully you will not have any issues ranin02 Apr 10, 2019 Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes.