Chloroquine base molecular weight

Discussion in 'Canada Drug' started by WmMaster, 18-Mar-2020.

  1. Danil_Kif Moderator

    Chloroquine base molecular weight


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Chloroquine phosphate, USP, a 4-aminoquinoline compound, is an antimalarial and amebicidal drug for oral administration. Chemically, it is 7-chloro-4-4-diethylamino-1-methylbutylamino quinoline phosphate 12 and has the following structural formula C 18 H 26 ClN 3 •2H 3 PO 4 - Molecular weight 515.87. Oral administration of 310 mg of chloroquine daily reportedly results in peak plasma concn of about 0.125 ug/mL. If 500 mg of chloroquine is administered once weekly, peak plasma concn of the drug reportedly range from 0.15-0.25 ug/mL and trough plasma concn reportedly range from 0.02-0.04 ug/mL.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine base molecular weight

    Quinine C20H24O2N2 - PubChem, Chloroquine Phosphate Tablets - Drug Information

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  3. Oct 09, 2018 Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg chloroquine base. In infants and children the dosage is preferably calculated by body weight. Adult Dose The dosage for prophylaxis is 500 mg = 300 mg base administered once per week on exactly the same day of each week.

    • DailyMed - CHLOROQUINE PHOSPHATE tablet.
    • Chloroquine C18H26ClN3 - PubChem.
    • Chloroquine sulfate C18H28ClN3O4S - PubChem.

    The mechanisms of action of hydroxychloroquine and chloroquine remain under continuous study in modern molecular medicine 17,18 using advanced tools in computational biology 19, synthetic biology. Chloroquine diphosphate salt Product Number C 6628 Store at Room Temperature RT Product Description Molecular Formula C18H26ClN3 • 2H3PO4 Molecular Weight 515.9 CAS Number 50-63-5 Melting point 193 °C Extinction coefficient EmM = 15 257 nm, 16.6 329 nm, 18.9 343 nm0.01 M HCl1 pKa 8.4 and 10.8 for chloroquine base at 20 °C 2 Chloroquine Phosphate. Molecular Formula C 18 H 29 ClN 3 O 4 P; Average mass 417.867 Da; Monoisotopic mass 417.158417 Da; ChemSpider ID 75637

     
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  5. dobberman Moderator

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  6. Prol New Member

    Antimalarial drugs Mode of action and status of resistance Mechanism of action and resistance, as well as status of resistance. studies indicated that chloroquine resistance was CHLOROQUINE Chloroquine was first synthesized in Germany, but it was not recognized as a potent antimalarial drug until the 1940s during the US World War II military effort. By 1946,

    Chloroquine - FDA prescribing information, side effects.
     
  7. Valdemar56 Moderator

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