Part of that is due to less exercise, part due to having no appetite thus feeling like anything I can get down is ok. Well, now I've been exercising at almost my pre-Lupus rate (ran a marathon a year before), eating a more moderate diet (clean protein, vegs & fruits), and am no longer taking that weight & bloat causing Prednisone (off Pred almost 2 yrs now). My question: Do you feel like you've gained weight on Plaquenil (ie without Prednisone)? Dosing of aralen Chloroquine malaria pills Apr 10, 2019 Common Plaquenil side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. Yes, Plaquenil causes both weight loss and loss of appetite. Hence, if the loss of appetite and weight loss started after you started on this drug, then yes, it could be due to Plaquenil. However, if you had loss of appetite and weight loss before your started this drug, then the drug can aggravate the process. RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. My Lupus has been really quiet for about 2 yrs, and I'm afraid to change anything. The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. My rheumy wants me to come down and then off my Plaquenil, but I've been resisting simply because I'm afraid to. Plaquenil side effects increased appetitie Will you have Appetite decreased with Plaquenil - eHealthMe, Plaquenil and loss of appetite - Lupus - MedHelp Screening criteria for ocular toxicity of plaquenilChloroquine bioavailability Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Common and Rare Side Effects for Plaquenil Oral. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. I know for sure that one of the side effects of plaquenil is lose of appetite, I would say its normal for now. Maybe once your body get use to it. You will go back to normal and start an joying your food. If your not losing weight or anything I don't think its a problem yet. Severe depression and anxiety, overall itching, pain and stiffness increased instead of decreased. First, my mother and sister took plaquenil for lupus with good effect, so I am not just disliking it for no good reason. I also suffer from disabling bipolar disorder. For 25 years, I have gotten hypomanic during spring. Plaquenil side effects include blurred vision, muscle weakness increased, mood changes, sore throat, fever, diarrhea, loss of appetite, nausea, vomiting, stomach pain, hair loss, skin rash etc. Headache is a symptom of an overdose.