Retinal thickness parameters as assessed by OCT have been studied extensively in clinical trials, however only modest correlation between these quantitative parameters and visual acuity among a variety of retinal diseases has been established. Advances in OCT technology, most importantly the advent of spectral-domain OCT, have enabled retinal images to be acquired at higher speed and resolution, making it easier to identify boundaries between subtle intraretinal layers In particular, the integrity of the photoreceptor layers as visualized using OCT has been demonstrated to have a more robust correlation with visual acuity than retinal thickness measurements alone, which has drawn attention to the continuity of these layers as possible predictive indicators of visual acuity in a wide variety of ophthalmic diseases that affect the macula. Chloroquine 250 mg dose Alternatives to plaquenil for sjogrens Incidence of alopecia with plaquenil Erosive inflammatory osteoarthritis EOA is a form of osteoarthritis OA where, as the name implies, there is an additional erosive/inflammatory component. In the outer retinal layers at the level of the IS/OS junction, we noted a focal loss or defect on the nasal and temporal side of the right macula. The left macula exhibited a similar presentation, but the line was not as bold and probably represented diffuse loss. SD-OCT images demonstrated loss of photoreceptor inner segment/outer segment IS/OS junction and a downward “sink-hole” displacement of inner retinal structures in areas of hydroxychloroquine toxicity corresponding to HVF 10-2 defects and ophthalmoscopic clinical examination findings. These bands have been extensively studied and their identities have been debated in an attempt to establish terminology that could facilitate communication in the field of ophthalmology. Spectral-domain optical coherence tomography image from the macula of a normal eye. Commercially available SD-OCT instruments have axial resolutions between 4 µm and 7 µm and transverse resolutions of approximately 15 µm, enabling the delineation of four hyper-reflective bands in the outer macula. Plaquenil is os junction Chloroquine and Hydroxychloroquine Maculopathy Case., Take a Shot at this Bull’s Eye - Review of Optometry Chloroquine for transduction Apr 15, 2015 2 The ellipsoid zone EZ, which was previously referred as the photoreceptor inner segment/outer segment IS/OS junction, is now thought to be formed mainly by mitochondria within the ellipsoid layer of the outer portion of the inner segments of the photoreceptors. Outer Retinal Layers as Predictors of Vision Loss. Spectral-Domain Optical Coherence Tomography and Adaptive.. PLAQUENIL - PLM. Three patients with early HCQ toxicity and HVF 10-2 perifoveal defects were found to have loss of the perifoveal photoreceptor inner segment/outer segment IS/OS junction with intact outer retina. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. In previous Windows operating system such as Windows XP, the closer thing to symbolic links is NTFS junction point, or worse, Windows shell shortcut.lnk file. Symlink in Windows, unlike shortcut in desktop or Windows Explorer, allow user to access files within the symbolic link created itself via File Explorer, the console and etc.