Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine generic and brand names Chloroquine toxicity eye Hydroxychloroquine urticaria angioedema Hydroxychloroquine originally from bark When treating lupus or arthritis, Plaquenil is usually given daily for several weeks or months. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 6 months of treatment. While using Plaquenil, you may need frequent blood tests and vision exams. Division of Rheumatology, Department of Internal Medicine, and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy. Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil pigmentation treatment Plaquenil Use in Autoimmune Diseases, Hydroxychloroquine-induced Hyperpigmentation of the Skin. Chloroquine and prescribing informationChloroquine myopathyChloroquine compatibilityHydroxychloroquine hypertensionIs plaquenil porcine based Hydroxychloroquine Plaquenil is not a new therapy. It has been used in rheumatology for decades and it's proven a very useful medication. Plaquenil Pigmentation - BJC Health. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Hydroxychloroquine-Induced Pigmentation in Patients With.. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Aug 14, 2013 Keywords Abuse, Dyschromia, Elderly, Hydroxychloroquine, Hyperpigmentation, Pigmentary disorders, Pigmentation Introduction Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1 – 5. Purpose Hydroxychloroquine HCQ is a systemic antimalarial used to treat cutaneous and systemic lupus erythematosus and other connective tissue diseases. Mucocutaneous hyperpigmentation is a well-documented side effect of HCQ that occurs in 10-25% of users.