Chloroquine for malaria treatment

Discussion in 'Canada Pharmacy' started by Radio Joy, 08-Mar-2020.

  1. freddilsd XenForo Moderator

    Chloroquine for malaria treatment


    For decades, the drug was a front-line treatment and prophylactic for malaria. In a three-page paper published Tuesday in Cell Research, scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology write that both chloroquine and the antiviral remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture.

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    Dec 13, 2018 Chloroquine phosphate. Chloroquine is the preferred treatment for any parasite that is sensitive to the drug. But in many parts of the world, the parasites that cause malaria are resistant to chloroquine, and the drug is no longer an effective treatment. Other common antimalarial drugs include Combination of atovaquone and proguanil Malarone Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Chloroquine This drug is taken once a week, starting about 1 to 2 weeks before your trip and continuing for 4 weeks after. But chloroquine is rarely used anymore, because it no longer works against P. falciparum, the most common and dangerous type of malaria parasite.

    “It’s interesting in that it really lacks a lot of details but, nevertheless, if you look at the data as presented, at least in vitro, it seems like chloroquine can be used as an early-stage drug,” he said. Their drug screen evaluated five other drugs that were not effective. Though the paper is brief, John Lednicky, a professor at the University of Florida’s Emerging Pathogens Institute, found its results intriguing.

    Chloroquine for malaria treatment

    WHO Guidelines for the treatment of malaria. Third edition, Chloroquine Oral Uses, Side Effects, Interactions.

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  6. Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided.

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    Chloroquine is an inexpensive antimalarial used for several decades and marketed in particular under the name of Nivaquine. This treatment is often recommended when planning to go to an area infested with the malaria parasite, transmitted by mosquitoes. Aralen chloroquine and Plaquenil hydroxychloroquine Aralen and Plaquenil are the first-line treatment for uncomplicated malaria without known drug resistance from Central America west of the Panama Canal, Haiti, the Dominican Republic, and most of the Middle East. In all cases of non-falciparum malaria P. vivax, P. ovale, P. malariae and P. knowlesi, it involves administration of chloroquine. Presumptive treatment for malaria involves administration of blood schizonticidal drugs, such as chloroquine, to suspected cases of malaria, followed by full treatment after confirmation. This strategy has been abandoned in recent years.

     
  7. alanex User

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. CU Anschutz Division of General Internal Medicine Interactions between Anesthesia S/I-60 Propofol. Anesthetic, General Inhalation Route, Parenteral Route.
     
  8. Asus New Member

    Interferes with digestive vacuole function within sensitive malarial parasites by increasing the p H and interfering with lysosomal degradation of hemoglobin; inhibits locomotion of neutrophils and chemotaxis of eosinophils; impairs complement-dependent antigen-antibody reactions Incomplete and variable (~70% [range: 25 to 100%]) (Tett 1993) Hepatic; metabolites include bidesethylchloroquine, desethylhydroxychloroquine, and desethylchloroquine (Mc Chesney 1966) Urine (15% to 25% [Tett 1993]; as metabolites and unchanged drug [up to 60%, Mc Chesney 1966]); may be enhanced by urinary acidification Rheumatic disease: May require several weeks to respond ~40 days (Tett 1993) ~40%, primarily albumin (Tett 1993) Lupus erythematosus: Treatment of chronic discoid erythematosus and systemic lupus erythematosus in adults. RA and Hydroxychloroquine How Effective is it for. Drug spotlight on hydroxychloroquine Lupus Foundation of. Losartan/hydrochlorothiazide Side Effects, Dosage, Uses, and More
     
  9. sapfira User

    Plaquenil caused me to go into menopause lupus Nobody seems to know how plaquenil works to treat lupus, but it must work by blocking cells' intake of estrogen. There is research to support this. Thus causing me to become perimenopausal. I don't know why more people don't report these side effects. Maybe they don't realize it's caused by the plaquenil.

    Hot flashes with plaquenil? DailyStrength
     
  10. Kicks Moderator

    Common and Rare Side Effects for Plaquenil Oral If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Deficiency Of Granulocytes A Type Of White Blood Cell.

    Oral health issues with lupus Lupus Foundation of America