Chloroquine resistant and sensitive areas

Discussion in 'Canadian Drugs' started by bk_man, 05-Mar-2020.

  1. artisgrp Well-Known Member

    Chloroquine resistant and sensitive areas


    Previously referred to as “Resochin”, Chloroquine was first discovered in 1924 at Bayer laboratories. Its first use was initially ignored as it was found to be toxic to people.

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    Drug resistance has been implicated in the spread of malaria to new areas and re-emergence of malaria in areas where the disease had been eradi-cated. Drug resistance has also played a significant role in the occurrence and severity of epidemics in some parts of the world. Population movement has introduced resistant parasites to areas. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It is taken by mouth. Common side effects include muscle problems, loss of appetite, diarrhea, and skin rash. Serious Both species are regarded as very sensitive to chloroquine, although there is a single recent report of chloroquine resistance in P. malariae. P. vivax is still generally very sensitive to chloroquine, although resistance is prevalent and increasing in some areas, notably Oceania, Indonesia and Peru.

    These trials showed that chloroquine eliminated malaria and was appropriate to be used as an antimalarial drug. Thus, it was not until World War II that the government of the United States sponsored the clinical trials of chloroquine as an antimalarial drug.

    Chloroquine resistant and sensitive areas

    A Molecular Marker for Chloroquine-Resistant Falciparum., Chloroquine - Wikipedia

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  7. Chloroquine is used for the prophylaxis of malaria in areas of the world where the risk of chloroquine-resistant falciparum malaria is still low. It is also used with proguanil when chloroquine-resistant falciparum malaria is present. However, this combination may not be ideal.

    • Malaria Prophylaxis. The ABCD of Malaria Prophylaxis..
    • Chloroquine C18H26ClN3 - PubChem.
    • Chloroquine resistant Plasmodium vivax review Worldwide..

    In all areas with CRPF, there is malaria caused by one or more other species of Plasmodium P. vivax, P. ovale, P. malariae that remain sensitive to chloroquine. In addition, chloroquine-sensitive P. falciparum may coexist with chloroquine-resistant parasites within a geographic area. Multi-drug resistant malaria In areas of Thailand near the borders with Cambodia and Myanmar and in Western Cambodia, P. falciparum infections do not respond to chloroquine or pyrimethamine-sulfadoxine, and sensitivity to quinine is reduced. Treatment failures of over 50% are also being reported. Chloroquine is the drug of choice for travel to areas where chloroquine resistance has not been described. Chloroquine is active against the erythrocytic forms Fig. 6.3 of sensitive strains of all species of malaria, and it is also gametocidal against P. vivax, P. malariae, and P. ovale.

     
  8. mudric Guest

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  9. photocoffe User

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