I didn't seem to have any problems whatsoever with it initially, other than very short term and mild cramping/diarrhea. But now I've been dealing with considerable muscle aching and pain/spasm in some new places - or at least places that haven't bothered me in quite awhile. Chloroquine otc uk Chloroquine pic High risk medication plaquenil icd 10 Malaria chloroquine primaquine and chloroquine phosphate Talk to your doctor about this, but my guess is that the Plaquenil is not doing anything to cause the pain, but rather that it is not doing enough to prevent it. It sounds like your RA has probably gotten a bit out of control, relative, to your current treatment, and Plaquenil is not a particularly potent drug when it comes to managing joint pain. It is prescribed as a disease-modifier, in other words, to decrease pain and swelling, and prevent joint damage and disability. There is evidence that hydroxychloroquine may interfere with communication between cells in the immune system. Anti-malarial medications have shown to improve muscle and joint pain, skin rashes, pericarditis, and other lupus symptoms such as fatigue and fever. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin. I felt the Plaquenil helped the fatigue, but it seems the pain is sabotaging that effect. My knees and legs hurt, back, hips, shoulders, fingers, and now my left heel - which has me limping half the time. Can plaquenil cause joint pain Will you have Joint pain with Plaquenil - eHealthMe, Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Hydroxychloroquine and azithromycinPlaquenil ratingPlaquenil and visual field testingDoes hydroxychloroquine affect menstrual cycle I started taking Plaquenil 4 weeks ago for non specific autoimmune disease as indicated by ANA. Symptoms were low grade temperature off and on for a year, joint pain and fatigue. I have already felt some relief. Some nauseau at first but less problem with fever and joint pain. But, now I have started having stomach cramps and diarrhea. I understand these may go away. Is there anything I can. Stomach problems with Plaquenil • Johns Hopkins Arthritis Center. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Can stopping Plaquenil cause joint pain to return?. I noticed plaquenil helping with my fatigue more so than anything else. It does help my joint pain but I need extra help from other meds too It can take up to 6 months to get in your system and fully work, each person is different. I pray it doesn't take that long for you to get some relief. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory pathways. Plaquenil is primarily used to help with some of the symptoms of Sjogren's.reduce fatigue, and joint pain. It is also thought it help slow progression but not well documented for this. It is not expected to halt the disease process and reverse your SFN.