What is the mechanism of action of chloroquine

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  1. Olejka Moderator

    What is the mechanism of action of chloroquine


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

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    It is caused by protozoan parasites belonging to the Plasmodium genus and transmitted by an infected female Anopheles mosquito. This disease affects mainly children aged less than 5 years. Among the four species of malarial parasite which infect humans. The mechanisms of chloroquine accumulation in the food vacuole have been proposed to be accumulation of chloroquine in the food vacuole as a result of increased acidity, presence of a carrier in the parasite and the presence of a receptor in the vacuole that chloroquine can bind to 10. General antimicrobial mechanism of action of chloroquine. Chloroquine accumulates in very high concentrations in the parasite food vacuole Geary et al. 1986. Once in the food vacuole, chloroquine is thought to inhibit the detoxification of heme. Chloroquine becomes protonated to CQ 2+ because the digestive vacuole is acidic pH 4.7

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    What is the mechanism of action of chloroquine

    Chloroquine - FDA prescribing information, side effects and uses, Chloroquine Resistance in Plasmodium falciparum - microbewiki

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  4. Chloroquine is the drug of choice in the few malaria-endemic areas free of CRPf. Combining chloroquine and proguanil is an option for CRPf when other first-line antimalarials are contraindicated. Dosage should be calculated in terms of the base. The adult chloroquine dose is 300 mg base weekly or in some countries 100 mg base daily.

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    Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Common side effects include vomiting, headache, changes in vision and muscle weakness. Severe side effects may include allergic reactions. Antiprotozoal-Malaria /Mechanism of action/ may be based on ability of chloroquine to bind and alter the properties of DNA. Chloroquine also is taken up into the acidic food vacuoles of the parasite in the erythrocyte. It increases the pH of the acid vesicles, interfering with vesicle functions and possibly inhibiting phospholipid metabolism. An important mode of action of chloroquine and hydroxychloroquine is the interference of lysosomal activity and autophagy.

     
  5. warpokemon Moderator

    Download PDF Many systemic medications may cause retinal toxicity. Accidental hydroxychloroquine overdose resulting in. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors. Protecting your eyesight when taking Plaquenil Lupus.
     
  6. Promoter UK Well-Known Member

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