Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Adverse effect of hydroxychloroquine Chloroquine side effects usmle The emergence and spread of fit artemisinin-resistant P falciparum parasite lineages, which then acquire partner drug resistance across the Greater Mekong subregion, threatens regional malaria control and elimination goals. Elimination of falciparum malaria from this region should be accelerated while available antimalarial drugs still remain. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. Background. The Greater Mekong subregion GMS of the Asia Pacific, which includes the countries of Cambodia, China Yunnan Province, Lao People’s Democratic Republic PDR, Myanmar, Thailand, and Vietnam, is the epicentre of artemisinin resistance. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. 1950s chloroquine resistance greater mekong subregion Meeting of the Greater Mekong Subregion GMS Therapeutic., Chloroquine - Wikipedia Hydroxychloroquine sulfate 200 mg Sep 29, 2017 Drug resistance in the Greater Mekong Subregion a brief history The GMS has long been the epicentre of antimalarial drug resistance. Parasites resistant to chloroquine were first detected in the late 1950s along the Cambodia–Thailand border. Antimalarial drug resistance in the Greater Mekong Subregion.. The challenge of artemisinin resistance can only be met by.. Determinants of dihydroartemisinin-piperaquine treatment.. The emergence and spread of fit artemisinin-resistant P falciparum parasite lineages, which then acquire partner drug resistance across the Greater Mekong subregion, threatens regional malaria. Background Intensive malaria transmission along international borders is a significant impediment to malaria elimination in the Greater Mekong Subregion GMS of Southeast Asia. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.