Hydroxychloroquine retinopathy still alive and well

Discussion in 'Canadian Pharmacy Online' started by SeDo4, 16-Mar-2020.

  1. zeeki New Member

    Hydroxychloroquine retinopathy still alive and well


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

    Chloroquine in lupus Plaquenil methotrexate rheumatoid arthritis Hydroxychloroquine combination arimidex

    HCQ retinopathy is, sadly, very much alive and well. Much of the responsibility for informing patients and initiating screening falls on rheumatologists because they are usually the primary doctor initiating use of the drug. The patient is at risk—and the physician is at risk medicolegally—if adequate screening is not performed. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloriquine, or Plaquenil, is a first line drug in the treatment of several autoimmune diseases including Sjogren's syndrome. The story underscores an important reminder to those taking the drug Get Plaquenil eye exams on a regular basis by a knowledgeable practitioner.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Hydroxychloroquine retinopathy still alive and well

    Spectral domain optical coherence. - PubMed Central PMC, Hydroxychloroquine-Induced Retinal Toxicity - American.

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  5. Rationale for Screening. Hydroxychloroquine and CQ retinopathy are not reversible, and cellular damage may progress even after the drugs are stopped. When retinopathy is not recognized until a bull’seye appears, the disease can progress for years, often with foveal thinning and an eventual loss of visual acuity.

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    Rates and Predictors of Hydroxychloroquine Retinal Toxicity in Patients With Rheumatoid Arthritis and Systemic Lupus Erythematosus FREDERICK WOLFE1 AND MICHAEL F. MARMOR2 Objective. Hydroxychloroquine HCQ retinopathy is of concern because of the potential seriousness of visual loss and the medicolegal consequences of failure to detect toxicity. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Plaquenil hydroxychloroquine sulfate, Sanofi-Aventis and the less-used chloroquine are antimalarial drugs with anti-inflammatory properties that are used for the management of a spectrum of inflammatory conditions.

     
  6. djairo Moderator

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Plaquenil Hydroxychloroquine Sulfate Alopecia Areata Signs, Treatment, Symptoms, Causes, In. La première patiente infectée au Covid-19 est guérie.
     
  7. softvista Well-Known Member

    Hydroxychloroquine DermNet NZ Hydroxychloroquine can cause irreversible retinal toxicity, resulting in bilateral bull’s eye retinopathy, but is regarded as less toxic to the retina than chloroquine and it does not cause the corneal deposits seen with chloroquine therapy.

    Chloroquine - Wikipedia