Chloroquine for malaria prophylaxis dosing

Discussion in 'Canadian Pharmacy' started by TaP3aH, 20-Mar-2020.

  1. sprymak Well-Known Member

    Chloroquine for malaria prophylaxis dosing


    Controlled studies in pregnant women show no evidence of fetal risk. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Animal studies show risk and human studies not available or neither animal nor human studies done. Contact the applicable plan provider for the most current information. D: Use in LIFE-THREATENING emergencies when no safer drug available.

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    Apr 02, 2019 The dosage of chloroquine phosphate is often expressed in terms of equivalent chloroquine base. Each 500 mg tablet of ARALEN contains the equivalent of 300 mg chloroquine base. In infants and children the dosage is preferably calculated by body weight. Irreversible retinal damage observed in some patients; significant risk factors for retinal damage include daily doses of chloroquine phosphate 2.3 mg/kg of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate, and concurrent macular disease. The pharmacokinetics of chloroquine were studied in healthy volunteers who received one of three different multiple-dose regimens for 3 weeks once weekly 300 mg, twice weekly 200 mg and once daily 50 mg chloroquine. Plasma concentrations of chloroquine and metabolites were determined by h.p.l.c. with fluorescence detection.

    Active against erythrocytic forms of Plasmodium vivax & P. malariae and most strains of Plasmodium falciparum Precise mechanism not known Bioavailability: ~89% Peak plasma time: 1-2 hr Distributed widely in body tissues (eg, eyes, heart, kidneys, liver, lungs) where retention prolonged; crosses placenta; enters breast milk Partially in liver Half-life: 3-5 days Excretion: urine (~70% as unchanged drug); acidification of urine increases elimination Small amounts may be present in urine months following discontinuation of therapy The above information is provided for general informational and educational purposes only.

    Chloroquine for malaria prophylaxis dosing

    Chloroquine Phosphate chloroquine phosphate dose., Aralen, Chloroquine phosphate chloroquine dosing.

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  5. Medscape - Indication-specific dosing for Aralen, Chloroquine phosphate chloroquine, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

    • Aralen, Chloroquine phosphate chloroquine dosing, indications..
    • The pharmacokinetics of three multiple dose regimens of..
    • Chloroquine Dosage & Rx Info Uses, Side Effects.

    Infections should receive chloroquine prophylaxis 300 mg base po once a week during pregnancy. After delivery, patients with normal G6PD activity should be treated with primaquine or tafenoquine or continue with chloroquine prophylaxis for a total of 1 year. Primaquine can be used during breastfeeding if the infant is found The standard chloroquine dose for treating malaria in adults is a one-time loading dose of 1000 mg, followed by 500 mg in six to eight hours. Then 500 mg is taken once a day for two more days. The standard dosage for malaria treatment in children is based on the child's weight. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.

     
  6. kr4shr Moderator

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Antirheumatic Drugs and the Risk of Tuberculosis Clinical. Tuberculosis TB Hydroxychloroquine Side Effects, Dosage, Uses, and More
     
  7. Alpes Well-Known Member

    We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising. Effects of chloroquine on viral infections an old drug. PDF Synthesis of New Chloroquine Derivatives as Antimalarial Agents Efficacy of Chloroquine for the Treatment of Uncomplicated Plasmodium.
     
  8. IlyaT Moderator

    Plaquenil Oral Uses, Side Effects, Interactions, Pictures. How to use Plaquenil. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy.

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  9. Ya_maika New Member

    Chloroquine Phosphate C18H29ClN3O4P ChemSpider Chloroquine Phosphate. Molecular Formula C 18 H 29 ClN 3 O 4 P; Average mass 417.867 Da; Monoisotopic mass 417.158417 Da; ChemSpider ID 75637

    Chloroquine - LiverTox - NCBI Bookshelf