Chloroquine resistant malaria mechanism

Discussion in 'Chloroquin' started by zxcv, 19-Mar-2020.

  1. spamer.. Moderator

    Chloroquine resistant malaria mechanism


    With concentrated malaria eradication efforts currently underway, monitoring drug resistance in clinical settings complemented by in vitro drug susceptibility assays and analysis of resistance markers, becomes critical to the implementation of an effective antimalarial drug policy. Understanding of the factors, which lead to the development and spread of drug resistance, is necessary to design optimal prevention and treatment strategies.

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    Chloroquine-resistant P. vivax malaria was first identified in 1989 among Australians living in or traveling to Papua New Guinea. P. vivax resistance to chloroquine has also now been identified in Southeast Asia, Ethiopia, and Madagascar. Isolated reports have suggested chloroquine-resistance P. vivax in other countries and regions, but further evaluation is needed. As drug resistance is genetically determined, it will spread by active malaria transmission, as gametocytes from resistant isolates will produce resistant offspring. Many African countries switched their fi rst-line drug to sulfadoxine- pyrimethamine SP; however, resistance to SP has grown and spread very quickly, especially in Southeast Asia, South America 4, 7 and more recently in many areas of Africa 8. Nov 19, 2010 Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen.

    The development of resistance to drugs poses one of the greatest threats to malaria control and results in increased malaria morbidity and mortality. This review attempts to summarize the unique factors presented by malarial parasites that lead to the emergence and spread of drug resistance, and gives an overview of known resistance mechanisms to currently used antimalarial drugs.

    Chloroquine resistant malaria mechanism

    Mechanisms of Resistance of Malaria Parasites to., Mechanisms of Antimalarial Drug Resistance SpringerLink

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  6. The emergence and spread of chloroquine-resistant Plasmodium falciparum malaria parasites has been a disaster for world health. Resistance is conferred by mutations in the Chloroquine Resistance.

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    Chloroquine resistant P. falciparum is now predominant in nearly all malaria endemic regions Fig. 1B, but despite widespread resistance, chloroquine maintains some clinical efficacy in areas where patients have acquired partial immunity to malaria premunition, through repeated infections. Chloroquine is used for the prophylaxis of malaria in areas of the world where the risk of chloroquine-resistant falciparum malaria is still low. It is also used with proguanil when chloroquine-resistant falciparum malaria is present. Prophylaxis of malaria in geographic areas where resistance to Chloroquine is not present. Treatment of extraintestinal amebiasis. Chloroquine phosphate tablets do not prevent relapses in patients with vivax or ovale malaria because it is not effective against exoerythrocytic forms of the parasites.

     
  7. valera88 XenForo Moderator

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. SAFETY DATA SHEET Page 1 of 6 Chloroquine phosphate. Chloroquine - FDA prescribing information, side effects. CHLOROQUINE PHOSPHATE, USP
     
  8. Socialiser New Member

    Also known as: Plaquenil, Quineprox The following information is NOT intended to endorse any particular medication. Treating Lupus with Anti-Malarial Drugs Johns Hopkins. Does anyone take methotrexate and hydroxychloroquine. - NRAS What step comes after plaquenil?
     
  9. Nicolas New Member

    Plaquenil and corona lupus Hi all, I'm living in Belgium, and corona is just starting to get pretty bad here. My sister-in-law, who is a doctor, told me that they are treating corona patients with plaquenil. I'm not saying it protects you all the way, but it seems to be effective enough to be implemented in hospitals here.

    Hydroxychloroquine - Wikipedia