Ongoing monitoring of blood counts, liver and kidney function is also required. Prescribed for Acute Lymphocytic Leukemia, Acute Lymphoblastic Leukemia, Rheumatoid Arthritis, Psoriatic Arthritis, Solid Tumors, Small Cell Lung Cancer, Systemic Sclerosis, Neoplastic Diseases, Trophoblastic Disease, Osteosarcoma, Non-Small Cell Lung Cancer, Non-Hodgkin's Lymphoma, Psoriasis, Mycosis Fungoides, Dermatomyositis, Breast Cancer, Choriocarcinoma, Meningeal Leukemia, Graft-versus-host disease, Head and Neck Cancer, Juvenile Idiopathic Arthritis, Lymphoma. Drug interations plaquenil Aralene Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in. Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications results of a two-year, randomized, double-blind, placebo-controlled trial, " Prescribed for Lyme Disease - Arthritis, Dermatomyositis, Malaria, Malaria Prevention, Rheumatoid Arthritis, Systemic Lupus Erythematosus. May also be prescribed off label for Bladder Cancer, Acute Nonlymphocytic Leukemia, Soft Tissue Sarcoma, Scleroderma, Pityriasis rubra pilaris, Pemphigus, Pemphigoid, Pancreatic Cancer, Ovarian Cancer, Mantle Cell Lymphoma, Brain Tumor, Bullous Pemphigoid, Cervical Cancer, Cogan's Syndrome, Colorectal Cancer, Ectopic Pregnancy, Eczema, Esophageal Carcinoma, Gastric Cancer, Hodgkin's Lymphoma, Uveitis. Methotrexate sulfasalazine and hydroxychloroquine TRIPLE THERAPY WITH METHOTREXATE, SULFASALAZINE, AND., Rheumatoid Arthritis Treatment Options Johns Hopkins. Plaquenil weight loss redditPlaquenil and lymphomaWhat is hydroxychloroquine forSmall bowel obstruction bowel obstruction take hydroxychloroquine O'Dell JR, Leff R, Paulsen G, et al. Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications results of a two-year, randomized, double-blind, placebo-controlled trial. REFERENCES - UpToDate. Methotrexate in combination with sulfasalazine is more.. Hydroxychloroquine Plaquenil RheumTutor. Methotrexate allows about 30% to 50% of early RA patients to achieve a low disease activity. Among the several potential DMARD Disease Modifying Anti-Rheumatic Drugs combinations, the combination of methotrexate MTX, sulfasalazine SSZ and hydroxychloroquine HCQ has been shown to be the most effective. Methotrexate is one of the most durable and frequently used disease-modifying antirheumatic drugs DMARDs in monotherapy as well as the cornerstone of combination therapy for rheumatoid arthritis RA. Leflunomide, sulfasalazine, and hydroxychloroquine are effective therapies in RA and are commonly employed in combination therapy. Conventional DMARDs that have been paired with methotrexate include sulfasalazine, hydroxychloroquine, cyclosporine, leflunomide and azathioprine. Although studies of these combinations have shown differing levels of benefit, the combinations of methotrexate plus leflunomide and methotrexate plus sulfasalazine are among the most effective.