I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Plaquenil and nephritis Plaquenil gut bacteria Many people using this medication do not have serious side your doctor immediately if any of these unlikely but serious side effects occur arm/leg/back pain, fast heartbeat, hair loss/color change, mental/mood changes e.g. anxiety, depression, hallucinations, ringing in the ears/hearing loss, worsening of skin conditions e.g. psoriasismedication may infrequently cause serious sometimes permanent eye problems or muscle damage, especially if you take it for a long time. The more common side effects that can occur with hydroxychloroquine include headache; dizziness; diarrhea; stomach cramps; vomiting; Mild side effects may go away within a few days or a couple of. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. Effects of stopping plaquenil Lupus Medicines Hydroxychloroquine - Brigham and Women's., Hydroxychloroquine Side Effects, Dosage, Uses, and More Cyclosporine and plaquenilPlaquenil classificationRecommended eye for sjogrens plaquenilHydroxychloroquine and trametinibCellcept prednisone and plaquenil for rheumatoid arthritis Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil Side Effects Common, Severe, Long Term -. Let me tell you what weaning down from Plaquenil is like.. Rx Side Effects New Plaquenil Guidelines and More.. Has anyone had any side effects from STOPPING plaquenil? Also - does anyone have any great ways to prevent virus and illness, when weak? I seem to get cold after cold after cold this year. I had a diagnosis of seronegative RA in 2017. After two years of plaquenil, my disease is in remission and we have me reduced now to only 100mg per day. Hydroxychloroquine Side Effects Get emergency medical help if you have signs of an allergic reaction hives; difficulty breathing; swelling of your face, lips, tongue, or throat. It didn't take me long to feel the effects of stopping. I guess I didn't realize how much it was helping me. So far I feel More tired Breathing is more difficult Feels like I am drowning Arms and legs are tingling Numb hands and feet Headache I don't know if this is the result of stopping Plaquenil or just how my Sarcoidosis is presenting.