Plaquenil corneal toxicity

Discussion in 'Chloroquine Online' started by bleff, 09-Mar-2020.

  1. lza XenForo Moderator

    Plaquenil corneal toxicity


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Hydroxychloroquine Plaquenil was originally used to treat malaria and is now used mostly to treat rheumatological and dermatological diseases. Its most frequent use now is for Rheumatoid Arthritis RA and Lupus and is often very effective in mitigating the joint and arthritic symptoms these diseases can cause. Plaquenil can prove toxic to the retina, threatening the vision. Regular eye examinations are essential for those patients taking plaquenil because over time the retina can become damaged beyond repair. Regular medical monitoring is the only way to ensure that toxicity is not occurring. Apr 20, 2011 Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Plaquenil corneal toxicity

    Has anyone experienced plaquenil toxicity with damage to eyes?, Plaquenil Eye Exams - Catalina Eye Care

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  7. The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin -containing structures in the body. With prolonged usage, metabolites in the drug accumulate in the retina. The drug remains in these parts even if the patients stopped taking the drugs.

    • Plaquenil Toxicity - Symptoms, Treatment, Risk Factors..
    • New Plaquenil Guidelines.
    • The Risk of Retinal Toxicity with Plaquenil - Sjogren's.

    Symptoms of Plaquenil toxicity are similar to other macular problems and may include Decreased fine vision or difficulty reading. Changes in Color vision. Missing Spots or shadows near the center of the vision. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug.

     
  8. Doc_seo New Member

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  9. orbiter Well-Known Member

    Drugs & Medications That Can Trigger Psoriasis Flare-Ups Some drugs that treat mental health issues like depression or bipolar disorder can make your psoriasis worse. They include fluoxetine Prozac, Sarafem and lithium. A few medications that treat anxiety, panic disorders, and sleep problems may affect your skin condition, too Alprazolam Niravam, Xanax

    A case of fatal hydroxychloroquine overdose