As an antimalarial drug, hydroxychloroquine has been shown to accumulate in malaria parasite lysosomes, increasing the p H. This activity interferes with the capacity of the parasite to hemoglobin proteolysis, stopping ordinary development and parasite replication. Plaquenil side effects bleeding High risk medication icd 10 plaquenil Greater mekong subregion chloroquine resistance Summary Insomnia is found among people who take Hydroxychloroquine sulfate, especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years, also take medication Enbrel, and have Pain. Plaquenil isn't known for causing insomnia. It is also a drug that stays in your system for a long time and takes a long time getting IN to your system. It takes 3-5 months to work and just as long to get out of your system. When you started the Plaquenil, how long did it take until you started having insomnia? Sleeping can be deceptive. Sjogren's certainly can cause pain and fatigue. But when the pain is widespread and insomnia is present, I find that a secondary fibromyalgia is usually also present – and treating this can result in dramatic improvement. Treatment for Dry Eyes and Mouth It is believed that hydroxychloroquine acts as a mild immunosuppressant, inhibiting rheumatoid factor production and acute phase reactants. As a disease-modifying anti-rheumatic drug (DMARD), the exact hydroxychloroquine mechanism of action is yet unknown. Can hydroxychloroquine cause insomnia Xeljanz A Blessing or a Curse for Rheumatoid Arthritis Patients?, Insomnia because of plaquenil DailyStrength Chloroquine injection for malaria treatmentChloroquine osteoarthritis Can hydroxychloroquine cause liver damage? Elevated liver enzymes are a common problem in some patients being treated with hydroxychloroquine, such as patients with lupus. However, as a general rule, hydroxychloroquine is not associated with an elevation in liver enzymes when used to treat autoimmune and rheumatologic diseases. Hydroxychloroquine Plaquenil Success, Reviews and Side Effects. Why There's More to Sjogren's Syndrome The Dr. Oz Show. Plaquenil Side Effects Common, Severe, Long Term -. Description and Brand Names. Drug information provided by IBM Micromedex US Brand Name. Plaquenil; Descriptions. Hydroxychloroquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines eg, chloroquine may not work. Hydroxychloroquine, a derivative of chloroquine, is frequently used as the first-line treatment, and it always results in rapid improvement within about a month of starting the treatment; however, recurrence is also common 5. The present patient responded well to hydroxychloroquine. Unfortunately, he had hypomnesis after administrated the drug. In the patients in whom corticosteroids are clearly contraindicated, chloroquine and hydroxychloroquine can play an important role. Furthermore, in patients with marked side effects of corticosteroids, particularly hyperglycemia, hydroxychloroquine can be of use not only as a corticosteroid-sparing agent but also as a blood glucose–lowering.