Is hydroxychloroquine antiviral

Discussion in 'Chloroquine Without A Doctor Prescription' started by boulatov, 14-Mar-2020.

  1. Serega1 New Member

    Is hydroxychloroquine antiviral


    Based on PBPK models results, a loading dose of 400 mg twice daily of hydroxychloroquine sulfate given orally, followed by a maintenance dose of 200 mg given twice daily for 4 days is recommended for SARS-Co V-2 infection, as it reached three times the potency of chloroquine phosphate when given 500 mg twice daily 5 days in advance. It's important to note that the study was examining use of chloroquine and hydroxychloroquine for treatment and prophylaxis of Covid19 infection (anti-viral activity) as well as postulating immuno-modulatory benefits against the 'cytokine storm' which precipitates later ARDS-type respiratory failure.

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    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2 Xueting Yao Drug Clinical Trial Center, Peking University Third Hospital, Mar 01, 2015 Hydroxychloroquine HCQ is an antimalarial drug also used in treating autoimmune diseases. Its antiviral activity was demonstrated in restricting HIV infection in vitro; however, the clinical implications remain controversial. Infection with dengue virus DENV is a global public health problem, and we lack an antiviral drug for DENV.

    As a doc with RA, I know that when my hydroxychlorquine dose is upped, I have to take the long view of 3 months when considering if it has helped with inflammation. The immunomodulatory benefits in the short term are not convincing since hydroxychloroquine used in a clinical setting for auto-immune disease is known to be maddeningly slow to show benefit.

    Is hydroxychloroquine antiviral

    In Vitro Antiviral Activity and Projection of Optimized Dosing Design., In Vitro Antiviral Activity and Projection of Optimized.

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  7. Chinese found an In Vitro activity of Plaquenil, and maybe in Vivo too but the live study is not yet published. A Professor in France got interested in doing a trial in Marseille hospital, and was agreed a few days ago to do so Pr Raoult; He is studying Plaquenil use in viral and intracellular.

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    Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Chloroquine and the 4-aminoquinoline drug hydroxychloroquine belong to the same molecular family. Hydroxychloroquine differs from chloroquine by the presence of a hydroxyl group at the end of the side chain the N-ethyl substituent is β-hydroxylated. This molecule is available for oral administration in the form of hydroxychloroquine sulfate. Hydroxychloroquine should be taken with a meal or a glass of milk to minimise the gastrointestinal side effects. Alternate-day dosing can be used. For example, hydroxychloroquine 400 mg alternating with hydroxychloroquine 200 mg daily can be used to reach effective daily dosing of 300 mg/day.

     
  8. promoman Moderator

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Hairloss-Lichen Planopilaris - Tom, I Could. Does Minoxidil Work on Frontal Hairline Baldness? - Hairguard Plaquenil/Hydroxychloroquine/Thinning Hair
     
  9. drmind Guest

    Zipsor (diclofenac potassium) is a nonsteroidal anti-inflammatory drug (NSAID). Is it dangerous and/or addictive to take Tylenol PM every. Plaquenil pros and cons - Sclero Forums MAIN - Sclero Forums Xanax helped me FINALLY sleep last night!
     
  10. DefFalmErardFer Moderator

    RheumNow Hydroxychloroquine Blood Levels in SLE MedPage. Hydroxychloroquine blood levels can be quantified by high performance liquid chromatography, which is a widely available means of measuring drug is also possible to measure serum.

    Does plaquenil hydroxychloroquine change blood test results, and which.
     
  11. K2K Well-Known Member

    Taking Plaquenil for Rheumatoid Arthritis The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more.   The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity.

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