Hydroxychloroquine-mediated retinopathy

Discussion in 'Chloroquine' started by Sys3X, 28-Feb-2020.

  1. rome.ro User

    Hydroxychloroquine-mediated retinopathy


    Ophthalmic surveillance was performed on patients in a multicenter clinical trial testing high-dose (1000 mg daily) hydroxychloroquine for advanced non–small cell lung cancer. The US Food & Drug Administration–recommended screening protocol included only visual acuity testing, dilated fundus examination, Amsler grid testing, and color vision testing.

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    Genetic Variants in Egyptian Patients Receiving HCQHydroxychloroquine HCQ The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Hydroxychloroquine is a front-line treatment for systemic lupus erythematosus and other rheumatic diseases, but can cause retinopathy. Improved detection techniques for the early stages pre. Autoimmune retinopathy associated with systemic lupus erythematosus A diagnostic dilemma. Taiwan J Ophthalmol 2017;2-6. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the

    Out of the 7 patients having exposure of at least 6 months, 2 developed retinal toxicity (at 11 and 17 months of exposure). In patients seen at Stanford, additional sensitive screening procedures were added at the discretion of the retinal physician: high-resolution spectral-domain optical coherence tomography (OCT), fundus autofluorescence (FAF) imaging, Humphrey visual field (HVF) testing, and multifocal electroretinography (mf ERG).

    Hydroxychloroquine-mediated retinopathy

    Intravitreal dexamethasone implant therapy for the., Hydroxychloroquine retinopathy — implications of research.

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  7. Diabetic retinopathy, one of the most serious complications of long-term diabetes, could clinically be divided into two stages 1 background retinopathy that does not cause visual impairment and 2 proliferative retinopathy, which is a potentially blinding condition. This study aims to investigate the correlation between enhancement of vascular endothelial growth factor VEGF expression.

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    • Incidence of hydroxychloroquine retinopathy in 1,207..

    Hydroxychloroquine binds strongly to melanin and can deposit in melanin-containing tissues such as the skin and the eyes, which might explain certain tissue-specific mechanisms such as. Retinopathy, hyperpigmentation, myopathy, and skin reactions.1 Retinopathy Retinopathy’s irreversibility—the threat of permanent vision loss—and its substantial prevalence in patients with a large drug expo-. a In patients with systemic lupus erythematosus SLE, hydroxychloroquine prevents disease flares and damage accrual and facilitates the response to mycophenolate mofetil in those with renal involvement. A study was undertaken to determine whether hydroxychloroquine also exerts a protective effect on survival.

     
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