Derm Net NZ Medical Editor: Dr Delwyn Dyall-Smith, Dermatologist, Wagga Wagga, NSW, Australia. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Derm Net NZ Editor in Chief: Adjunct Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Hydroxychloroquine is preferred due to its safer profile. Chloroquine price philippines Metoprolol and plaquenil interaction The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. These compounds lead to improvement of clinical and laboratory parameters, but their slow onset of action distinguishes them from glucocorticoids and nonsteroidal antiinflammatory agents. Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine is also used. Plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. This drug is also effective at preventing lupus flares. Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. If there is a of hydroxychloroquine, although studies have not usually confirmed this clinical impression. Hydroxychloroquine lupus mechanism Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus., Hydroxychloroquine - Side Effects, Dosage, Interactions. Cellulitis of leg and plaquenilPlaquenil sjogren& 39Plaquenil rash images Hydroxychloroquine Plaquenil is also a disease-modifying anti-rheumatic drug DMARD used to treat both acute and chronic rheumatoid arthritis, systemic lupus erythematosus, and discoid lupus erythematosus. Hydroxychloroquine likely works in the prevention and treatment of malaria by interfering with the parasite's normal growth and replication process. Hydroxychloroquine Plaquenil Success, Reviews and Side.. How is plaquenil hydroxychloroquine used to treat lupus?. Hydroxychloroquine. But, the use of the drug expanded in part due to observations made during World War II. Many people were using quinine or synthetic versions of it to prevent malaria. Doctors noticed that rheumatic symptoms improved when taking quinine, which led to the use of medications like Plaquenil to combat lupus. Hydroxychloroquine is classified as an anti-malarial drug. It is similar to chloroquine Aralen and is useful in treating several forms of malaria as well as lupus erythematosus and rheumatoid arthritis. Its mechanism of action is unknown. Malarial parasites invade human red blood cells. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Fox RI1. Author information 1Department of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, CA 92037. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus.