Long-term progression of hydroxychloroquine retinopathy off the drug marmor

Discussion in 'Generic Chloroquine' started by Natant, 19-Mar-2020.

  1. GrandAgr Moderator

    Long-term progression of hydroxychloroquine retinopathy off the drug marmor

    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    One study identified the utility of monitoring tests to detect progression in patients diagnosed with hydroxychloroquine retinopathy 13 to 40 months after the drug was discontinued. The potential for chloroquine phosphate and hydroxychloroquine sulfate retinopathy to progress after cessation of the drug has long been recognized, 1 - 4 primarily in patients with severe ring scotoma or a visible bull’s-eye lesion in the fundus. Such progression could continue for many years after the drug was stopped. Pham BH, Marmor MF. Sequential changes in hydroxychloroquine retinopathy up to 20 years after stopping the drug Implications for Mild Versus Severe Toxicity. Retina. 2019;2–501. CAS; Article

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Long-term progression of hydroxychloroquine retinopathy off the drug marmor

    AMERICAN COLLEGE OF RHEUMATOLOGY, Progression of Hydroxychloroquine Retinopathy - JAMA

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  3. Progression of Hydroxychloroquine Toxic Effects After Drug Therapy Cessation New Evidence From Multimodal Imaging. and long-term follow-up of patients with hydroxychloroquine retinopathy.

    • Progression of Hydroxychloroquine Toxic Effects After Drug..
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    Oct 16, 2014 Hydroxychloroquine is often prescribed as long-term therapy for many dermatologic indications, and it may have broader benefits e.g. preventing or improving thrombophilia associated with lupus erythematosus, neonatal lupus erythematosus, diabetes in rheumatoid arthritis and other connective tissue diseases, and as adjunctive therapy in some cancers. PURPOSE To characterize the stability or progression of different stages of hydroxychloroquine HCQ retinopathy up to 20 years after stopping the drug. METHODS We reviewed findings from 13 patients with initial HCQ retinopathy classified as early patchy photoreceptor damage, moderate ring of photoreceptor thinning or scotoma, or severe retinal pigment epithelial RPE damage. Apr 26, 2019 Lally DR, Heier JS, Baumal C, Witkin AJ, Maler S, Shah CP, et al. Expanded spectral domain-OCT findings in the early detection of hydroxychloroquine retinopathy and changes following drug.

  4. lerucencia Well-Known Member

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  5. roflmao Guest

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Rx Side Effects New Plaquenil Guidelines and More. Weight gain while on Plaquenil? lupus Plaquenil and loss of appetite - Lupus - MedHelp
  6. markofka Moderator

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  7. Armani777 New Member

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