Chloroquine injection during pregnancy

Discussion in 'Health Canada Drug Database' started by Okeana, 25-Feb-2020.

  1. 001dark Well-Known Member

    Chloroquine injection during pregnancy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine Adults 300 mg base 500 mg salt, once/week. Children 5 mg/kg base 8.3 mg/kg salt maximum is adult dose, once/week. Begin 1-2 weeks before travel, once/week during travel, and for 4 weeks after leaving. Some people would rather take medicine weekly; Good choice for long trips because it is taken only weekly The purpose of this study is to test prevention strategies for pregnancy-related malaria. Researchers will compare different malaria treatments and treatment schedules which include chloroquine therapy weekly doses versus being dosed twice during pregnancy for 3 days each time to the standard practice of preventive treatment intervals in pregnancy with the drug sulfadoxine-pyrimethamine. Tetanus/Diphtheria/ Tdap Tdap should be administered during pregnancy, preferably during the third trimester or late second trimester after 20 weeks of gestation.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine injection during pregnancy

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  5. The pharmacokinetics of most antimalarial drugs are also modified in pregnancy and dosages will need to be adapted. Other factors, including HIV status, drug interactions with antiretrovirals, the influence of haematinics and host genetic polymorphisms may influence safety and efficacy.

    • Antimalarial drugs in pregnancy a review..
    • Vaccination During Pregnancy - Cleveland Clinic.
    • Quinine and Pregnancy - Malaria Home Page.

    There is no evidence that chloroquine is harmful in prophylactic doses during pregnancy. Because of the susceptibility of pregnant women to falciparum malaria, it should be used at the recommended dosage for both prophylaxis and treatment wherever chloroquine-sensitive malaria is prevalent. According to the Centers for Disease Control and Prevention CDC, chloroquine is considered safe to use during pregnancy. Tell your doctor if you're pregnant or might become pregnant while taking. Apr 13, 2019 Ten women who were taking oral chloroquine 300 mg/week of chloroquine during pregnancy were changed to a dose of 100 mg/day for the last 10 days of pregnancy and first 10 days postpartum. Milk samples were taken daily for 3 days during the first 10 days postpartum at the end of nursing time after dose unspecified.

     
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