One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Side effects of long term plaquenil use Otis pregnancy fact sheets plaquenil Chloroquine mechanism of action in sle Plaquenil dose toxicity WebMD provides common contraindications for Plaquenil Oral. Find out what health conditions may be a health risk when taken with Plaquenil Oral Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists. Tracking of drusen and disease of the RPE as well as atrophy July 2011 July 2012 Advanced RPE analysis of RPE atrophy 68 year old with AMD and new vision loss OD Photoreceptor Integrity Line = PIL External Limiting Membrane= ELM 54 year old woman taking Plaquenil Ganglion Cell Complex The retinal ganglion cell and inner plexiform It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Drusen plaquenil Autofluorescence of Basal Laminar Drusen, Hydroxychloroquine Retinopathy Still Alive and Well - The. Plaquenil and the sunChloroquin functional groupsChloroquine toxicity antidote Multimodal imaging set showing drusen-like deposits DLDs affecting both eyes in a patient diagnosed with systemic lupus erythematosus SLE. In the color fundus photographs Top/Third rows, left, DLDs are seen as multiple yellowish lesions of different sizes spread across the posterior pole, but mainly located in the temporal region. Drusen-like Deposits in Young Adults Diagnosed With Systemic Lupus.. OCT Interpretation in Retinal Disease. Spectral domain optical coherence. - PubMed Central PMC. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Disease Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug. Basal Laminar Drusen. Basal laminar drusen is a condition in which yellow round deposits of lipid waste accumulate between the base of the retinal pigment epithelium and Bruch's membrane in the outer retina. These lesions appear in young adulthood as opposed to the drusen of age related macular degeneration which develop in late life.