Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine drug classification Side effects from plaquenil on eye Chloroquine phosphate reef central Leflunomide. Leflunomide is a disease modifying anti-rheumatic drug DMARD developed specifically to control inflammatory arthritis. DMARDs act slowly, over weeks and months. Leflunomide is a prodrug, which means that it is inactive until it is taken. It is changed into the active drug inside the person's own body. Clinical trials in patients with pSS using leflunomide LEF or hydroxychloroquine HCQ previously effectively inhibited B cell hyperactivity, but induced only modest insignificant effects on clinical parameters. LEF and HCQ have complementary inhibitory properties on different immune cells, including B cells, T cells and pDCs. Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon. For patients taking hydroxychloroquine to prevent malaria Hydroxychloroquine may also be used for purposes not listed in this medication guide. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Using hydroxychloroquine and leflunomide together Anxiety, depression and suicidal ideation in patients with., Clinical Efficacy of Leflunomide/Hydroxychloroquine. Chloroquine drug 13000Is plaquenil still manufacturedBenefits of taking plaquenil Patients received treatment with leflunomide and methotrexate and 133 subjects were randomized to placebo and methotrexate. The response rate of ACR20 criteria P0.001 at week 24 was 46.2% and 19.5% for the leflunomide and placebo groups respectively. The Combination of Leflunomide Arava. - Arthritis Information. Hydroxychloroquine Oral Route Proper Use - Mayo Clinic. Traditional DMARDs Methotrexate, Leflunomide, Sulfasalazine.. Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America. Rheumatoid Arthritis Drugs Pros and Cons. Rheumatoid arthritis can’t be cured, but joint pain and other symptoms can be managed. Some drugs fight inflammation and ease pain, while others help. Learn about drug interactions between hydroxychloroquine oral and leflunomide oral and use the RxList drug interaction checker to check drug combinations.