I am not shocked about having it just being diagnosed with it. I have seen my rheumatologist for five years and I guess she just thought it was time. Plaquenil drug interactions Rheumatoid arthritis treatment plaquenil mono Does hydroxychloroquine have renal toxicity Plaquenil and diarrhea does it stop Oct 12, 2016 In multivariable models, more weight loss and a greater risk of weight loss odds ratio 1.73 were evident among those receiving leflunomide compared to those receiving methotrexate. Treatment with prednisone was associated with greater weight gain—an average of 0.072 kg/m2. I recently went on Plaquenil a few months ago, and I have been noticing how much weight I've been losing. I feel like I am losing too much weight. I am a thin person, and I am sick very often. Last week, I lost three pounds, and the week before I lost two pounds. Everyone keeps commenting that I'm. Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. She tried to put me on it two years ago even before she diagnosed me because she has always suspected lupus. Anyway, I'm scared to death to take plaquenil but I know that I probably should. Weight loss methotrexate and plaquenil Rheumatoid Arthritis Treatment Options Johns Hopkins., Plaquenil and weight loss DailyStrength Chloroquine clinical trials cancerSpotfin lionfish and chloroquineDoes plaquenil keep you awake Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Compare Plaquenil vs Methotrexate -. Methotrexate and plaquenil -. Abnormal Weight Gain and Gut Microbiota Modifications Are.. Does anyone know if hydroxychloroquine and methotrexate can cause weight loss. I take metho 2.5mg weekly and 5 mg folic weekly and hydrox 200 mg twice a day, been taking for over a year now but although it helps with some of the pain. I am not sure what your question is, but Plaquenil is very well tolerated at the dose of 400 mg daily. If you are a very small person your rheumatologist may wish to decrease the daily maintenance dose, but I know that many patients are continued on the 400 mg daily dose for long periods. Jan 25, 2012 Regular plaquenil eye exams should quell concerns about eye complications, which are very rare. I was advised to take it at bed time, so I would sleep through any other side effects it might cause me, but I never noticed any side effects at all -- except feeling a lot better, less fatigue, less joint pain, and fewer issues overall.