My rheumy thinks in the long run plaquenil will not be enough for me and I will have to go to the next step. My question is, if plaquenil doesn't work, what is the next step of medication? Massive hydroxychloroquine overdose Synthesis of chloroquine from m chloroaniline Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. If tranexamic acid doesn’t work for you, or if the side effects are bothersome, your doctor may suggest alternative medications for heavy periods. This might include NSAIDs, a hormonal IUD, oral. My rheumy thinks in the long run plaquenil will not be enough for me and I will have to go to the next step. My question is, if plaquenil doesn't work, what is the next step of medication? Rheumy is very conservative with meds and always looks for the smallest dose possible and the least amount of meds. But the way my joint and skin pain has been going I may need bigger guns. Rheumy is very conservative with meds and always looks for the smallest dose possible and the least amount of meds. What if plaquenil doesn't work Hydroxychloroquine Side-effects, uses, time to work, Tranexamic Acid Side Effects and Possible Drug Interactions Chloroquine resistant areaAntiboptics and plaquenilSickle cell disease guidelines hydroxychloroquineHydroxychloroquine side effectsTaking two plaquenil instead of 1.5 Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. PLAQUENIL" Rheumatoid Arthritis Community - Support Group. What step comes after plaquenil?. Plaquenil Use in Autoimmune Diseases. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Hi - I have just had the same problem and my consultant has recommended that the next step is to take methotrexate via injection; and if this doesn't work after 6 months he is going to try another drug which I can't remember the name of will find out and post.