I can say that the prednisone wean was successful, even after having only been on plaquenil a few months. To answer some of your other questions, it was the same timeframe for me. Chloroquine diphosphate lysosome Can plaquenil make you tired Nonetheless, studies of the use of antimalarial agents in rheumatoid arthritis have suggested that hydroxychloroquine is tolerated well and that withdrawal from treatment on account of adverse. Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. I don't know if anyone can help as this isn't technically lupus related. I've been on plaquenil for 6 months for suspected Sjogren's syndrome I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil. But I couldn't handle the heart issue and not being able to breathe (plus all the other pains). Yesterday would've been my 4th day at the reduced dose. Withdrawal symptoms of hydroxychloroquine Will you have Withdrawal syndrome with Plaquenil - eHealthMe, Hydroxychloroquine Uses, Dosage & Side Effects - What eye exam is needed for plaquenilPlaquenil elimination half life We evaluated the long-term effectiveness of maintaining treatment with hydroxychloroquine sulphate HCQ to prevent major flares in quiescent SLE. Forty-seven patients with quiescent SLE who had been randomized to take HCQ n = 25 or placebo n = 22 as part of a 24-week withdrawal trial were evaluated for an additional 3 years. A Long-Term Study of Hydroxychloroquine Withdrawal on.. Hydroxychloroquine plaquenil withdrawl? - LUPUS UK. HYDROXYCHLOROQUINE - ORAL Plaquenil side effects, medical.. Hydroxychloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito. However, this medicine is not used to treat severe or complicated malaria. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues.