Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Plaquenil for lyme arthritis Plaquenil and prednisone during pregnancy Plaquenil use and weight and maculopathy Retinal lesions associated with chloroquine, although more rarely encountered, have proved to be irreversible. 20/200 in the right eye and 20/50 in the left eye. External examination of the eyes and intraocular pressures were within normal limits. Biomicro-. The occurrence of macular lesions in pa. Disease Entity. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been article focuses upon hydroxychloroquine retinopathy. We herein report the optical coherence tomography OCT findings in a case of chloroquine-induced macular toxicity, which to our knowledge, has so far not been reported. A 53- year-old lady on chloroquine for treatment of rheumatoid arthritis developed decrease in vision 36 months after initiation of the treatment. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Chloroquine eye exam for macular lesions Exams for PLAQUENIL and High Risk Medications, Hydroxychloroquine toxicity - EyeWiki Plaquenil and losing weight Jul 30, 2019 Applies to chloroquine compounding powder, injectable solution, oral tablet. Ocular. Maculopathy and macular degeneration may be irreversible. Irreversible retinal damage has been reported in patients receiving long-term or high-dose 4-aminoquinoline therapy. Retinopathy has been reported as dose related. Chloroquine Side Effects Common, Severe, Long Term -. Optical coherence tomography in a patient with chloroquine.. Protecting your eyesight when taking Plaquenil Lupus.. Mechanism It is metabolized to oxalic acid which combines with calcium to form insoluble calcium oxalte salt. This is deposited in various body tissues & the RPE & inner retina in the eye. Ocular signs Fundus – numerous yellow-white punctate lesions in the posterior pole & periarterially. Clofazimine The macular changes are potentially serious and are related to dosage and length of time taking hydroxychloroquine. Blurred vision and defective color vision may be found early. Advanced retinopathy is characterized by marked reduction of visual acuity and a “bulls eye” macular lesion which is absent in early involvement. Definition Bull’s eye maculopathy describes a number of different conditions in which there is a ring of pale-looking damage around a darker area of the macula. The macula can often appear to have circular bands of different shades of pink and orange.