Chloroquine pharmacokinetics

Discussion in 'Northwest Pharmacy' started by Leshanya, 10-Mar-2020.

  1. Yakuman New Member

    Chloroquine pharmacokinetics


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

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    Jan 19, 2010 Pharmacokinetics of chloroquine in Thais plasma and red-cell concentrations following an intravenous infusion to healthy subjects and patients with Plasmodium vivax malaria. Br. J. Hydroxychloroquine HCQ and chloroquine CQ are well absorbed 0.7-0.8 bioavailability when given orally. Severe malnutrition such as kwashiorkor effects absorption but diahrrea does not. Both HCQ and CQ have prolonged half-lives, between 40 and 50 days, and low blood clearance e.g. hydroxychloroquine's blood clearance is 96 ml/min. Pharmacology Pharmacokinetics. Hydroxychloroquine has similar pharmacokinetics to chloroquine, with rapid gastrointestinal absorption and elimination by the kidneys. Cytochrome P450 enzymes CYP2D6, 2C8, 3A4 and 3A5 metabolize hydroxychloroquine to N-desethylhydroxychloroquine. Pharmacodynamics

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Chloroquine pharmacokinetics

    Chloroquine C18H26ClN3 - PubChem, Pharmacokinetics of hydroxychloroquine and chloroquine.

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  5. The pharmacokinetics of hydroxychloroquine were found to be enantioselective. The concentrations of −‐R‐hydroxychloroquine were higher than those of the +‐S‐antipode in all patients at all time points, although the ratios of the two enantiomers did display a two to three fold variability between patients.

    • Pharmacokinetics and pharmacodynamics of hydroxychloroquine..
    • Hydroxychloroquine - Wikipedia.
    • Clinical Pharmacokinetics and Metabolism of Chloroquine..

    Professional guide for Chloroquine. Includes pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Chloroquine is deposited in the tissues in considerable amounts. In animals, from 200 to 700 times the plasma concentration may be found in the liver,spleen, kidney, and lung; leukocytes also concentrate the drug. The brain and spinal cord, in contrast, contain only 10 to 30 times the amount present in plasma.

     
  6. ilia26 Well-Known Member

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  7. serg_seo User

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  8. cashersmart Moderator

    Hydroxychloroquine Sulfate - an overview ScienceDirect Topics Hydroxychloroquine and chloroquine are given, for instance for SLE. Both belong to the group of 4-aminochinolines and have similar pharmacological characteristics, whereby, hydroxychloroquine is somewhat more potent, so that 400 mg of hydroxychloroquine sulfate approximately corresponds to

    Hydroxychloroquine Professional Patient Advice -
     
  9. renek Moderator

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