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    Accutane is derived from Vitamin A, which has been used to fight acne since 1930. Different companies have developed numerous Vitamin-A based acne treatments over the years, including retin-A, isotretinoin and Accutane. Before the release of Accutane, severe acne was primarily treated with oral antibiotics like tetracyclines and erythromycin. While these drugs worked for some patients, they were only effective against one of the bacteria that cause acne, Propionibacterium. Over time, these antibiotics grew less and less effective as the bacteria developed more resistant strains. Another early method of treating acne was to use high doses of fat soluble vitamin A. By using doses as high as 500,000 IU per day, researchers noticed lower rates of sebum, however, dry hair and other significant side effects kept the method from being used in a widespread manner. Accutane — the drug that cleared severe acne but was also linked to depression, suicidal thoughts and fetal deformities — is still on the market in its generic form, isotretinoin. How can this be, given that the original drug was discontinued by its manufacturer Hoffmann-La Roche, in part due to lawsuits relating to inflammatory bowel diseases and other issues? With intense patient screening, compliance protocols and careful monitoring, isotretinoin (eye-soh-tret-in-OH-in) can be effective and the risk of terrible side effects can be minimized. Isotretinoin is not without problems, however, so patients need to weigh the risks and the benefits before taking the drug. Here are 9 things you should know about isotretinoin. They can help you gauge whether it is a drug you want to take yourself or have prescribed for your teen to treat severe acne. In 1982, the US Food and Drug Administration () approved the active ingredient isotretinoin for use in treating severe nodular acne, under the brand name Accutane.

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