Depending on your fertility issues or overall health, a doctor might prescribe drugs other than clomiphene. Clomiphene can help men who have a hormonal imbalance linked to low sperm count, or poor sperm quality or motility. Clomiphene treatment can be an emotionally intense process for some women because they're anxious about their body's response to the medication. Women taking clomiphene also have to go to the doctor's office frequently for monitoring. Here's how it works: It depends on how regular a woman's menstrual cycle is and how many times she has to try before she gets pregnant. It can take a month or two of drug therapy – with a dosage increase, if necessary – before ovulation begins. Once ovulation occurs, it can take three to six cycles of treatment. Most doctors don't recommend using clomiphene for more than six treatment cycles. 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