If you are one of many people getting on Zoloft and are worried about feeling high or euphoric on Zoloft, don’t. Getting high on Zoloft doesn’t happen very frequently. And if you want to use Zoloft to get high, don’t bother. Zoloft is a type of medicine used to treat anxiety and depression. Zoloft is from a new class of antidepressants called selective serotonin reuptake inhibitors (SSRIs) and is thought to work by increasing the amount of serotonin in the brain, which changes the brain’s receptors to serotonin, making them more sensitive to this particular chemical. Similar and popular medications in this class of drugs includes Prozac and Trazodone. The end result of using SSRIs is increased perceptions of happiness and fullness and decreased perception of pain. In other words, taking Zoloft can increase your quality of life. 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Author information 11st Clinic of Internal Diseases and Acute Poisonings, Medical University of Gdańsk, Poland. [email protected] is a potent anticholinergics, rarely used as a drug of abuse. Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Show More Sertraline is used to treat depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder). This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. The selective serotonin reuptake inhibitor known as Zoloft is a medication used to treat depression, panic attacks, obsessive-compulsive disorder, post-traumatic stress disorder, social anxiety disorder and a severe form of premenstrual syndrome. Also known by its generic name, sertraline, this drug works by helping to restore the balance of a certain natural substance (serotonin) in the brain. It is prescribed to improve one’s mood, sleep, appetite, and energy level and has been known to restore interest in daily living in those suffering from depression. In patients suffering from social phobias, it may decrease fear, anxiety, unwanted thoughts and the number of panic attacks. For those with OCD, sertraline may reduce the urge to perform repeated tasks, including compulsive hand-washing, counting and touching. Zoloft is known as one of the most prescribed and readily available prescription antidepressants, and this, in turn, makes it easy to misuse. 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