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    Gabapentin, also referred to as Neurontin, was initially distributed for the treatment of epilepsy. Our question today is from Alison in Portland, Oregon. Before taking them, however, it’s important to understand what each one is and does. Sometimes Zoloft and Gabapentin are prescribed to be taken together if the Zoloft is not quite doing the trick. Over the years, researchers found that Gabapentin also has a positive effect on the relief of neuropathic pain, restless leg syndrome, bipolar disorder, anxiety disorder, depression, insomnia, and several other disorders. Zoloft, on the other hand, is a serotonin reuptake inhibitor or SSRI. This one is most commonly prescribed to treat depression, anxiety, panic attacks, and OCD. One may feel relaxed when combining the two; however, it’s not unusual to experience drowsiness, difficulty concentrating, and dizziness when taking these medications together. Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo.

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